David Exposito-Alonso


I am a postdoctoral researcher in the Walsh Lab at Boston Children’s Hospital and Harvard Medical School. My work is focused on investigating mechanisms of brain development and connectivity and the functional impact of genetic mutations associated with neurodevelopmental disorders. The ultimate goal is to better understand the developmental trajectories of brain disorders to provide new insights into the development of effective therapies.


Research


I am interested in understanding how neuronal circuits are formed and function in the developing brain. Specifically, I investigate molecular and synaptic mechanisms regulating the development and maturation of the cerebral cortex, a brain region involved in higher-order cognitive function, and how cortical circuits have changed as a result of evolutionary genetic adaptations.


Ongoing work

Brain Development and Wiring

What molecular and cellular mechanisms regulate the formation of synaptic connections during brain development?

Evolution of the Cerebral Cortex

How have genetic changes in the human genome remodeled the organization of circuits in the cerebral cortex during evolution?

Neurodevelopmental Disorders

Which signaling pathways are impaired in neurodevelopmental disorders? How (and when) the developmental trajectories of the brain are affected by genetic mutations?

David Exposito-Alonso

Walsh Laboratory in the Division of Genetics & Genomics

Boston Children’s Hospital and Harvard Medical School

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Contact

Center for Life Science, 15th Floor
3 Blackfan Circle, Boston, MA 02115

david.exposito-alonso@childrens.harvard.edu